Structure of PDB 2zhw Chain H

Receptor sequence

>2zhwH (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF

3D structure

PDB

2zhw Exploring thrombin S3 pocket

Chain

Resolution

2.02 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	H	E23 I24 M26 P28 W29 D116 H119 C122 Y134 K135 G136 R137 N159 M201 K202 R206 W207	E8 I9 M11 P13 W14 D113 H116 C119 Y134 K135 G136 R137 N156 M203 K204 R210 W211
BS02	peptide	H	F34 L65 R67 R73 T74 R75 Y76 I82 M84	F19 L60 R62 R68 T69 R70 Y71 I78 M80
BS03	12U	H	H57 Y60A W60D D189 A190 G216	H43 Y47 W50 D191 A192 G220

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2zhw, PDBe:2zhw, PDBj:2zhw
PDBsum	2zhw
PubMed
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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