Structure of PDB 2zhf Chain H

Receptor sequence

>2zhfH (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF

3D structure

PDB

2zhf Exploring thrombin S3 pocket

Chain

Resolution

1.98 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N156 M203 K204 N209 R210 W211
BS02	peptide	H	F34 Q38 L40 L65 R73 T74 Y76 K81 I82	F19 Q24 L26 L60 R68 T69 Y71 K77 I78
BS03	49U	H	H57 Y60A W60D L99 D189 A190 S195 V213 S214 W215 G216 G219	H43 Y47 W50 L96 D191 A192 S197 V217 S218 W219 G220 G222	BindingDB: Ki=1180nM

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2zhf, PDBe:2zhf, PDBj:2zhf
PDBsum	2zhf
PubMed
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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