Structure of PDB 2zgx Chain H

Receptor sequence
>2zgxH (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
3D structure
PDB2zgx Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin
ChainH
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H E23 G25 M26 W29 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207 E8 G10 M11 W14 H116 P117 C119 Y134 K135 R137 N156 M203 K204 N209 R210 W211
BS02 peptide H F34 Q38 L40 L65 R73 T74 R75 Y76 K81 I82 F19 Q24 L26 L60 R68 T69 R70 Y71 K77 I78
BS03 29U H H57 Y60A W60D D189 A190 V213 W215 G216 H43 Y47 W50 D191 A192 V217 W219 G220 MOAD: Ki=180nM
PDBbind-CN: -logKd/Ki=6.74,Ki=180nM
BindingDB: Ki=180nM,Kd=110nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2zgx, PDBe:2zgx, PDBj:2zgx
PDBsum2zgx
PubMed19520086
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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