Structure of PDB 2zf0 Chain H

Receptor sequence

>2zf0H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G

3D structure

PDB

2zf0 Exploring Thrombin S1 pocket

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	H	E23 G25 M26 P28 W29 S48 D49 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 P204 N205 R206 W207	E8 G10 M11 P13 W14 S34 D35 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 P207 N210 R211 W212
BS02	peptide	H	F34 K36 Q38 L65 R73 T74 Y76 K81 I82	F19 K21 Q24 L60 R68 T69 Y71 K77 I78
BS03	51U	H	Y60A W60D N98 A190 C191 V213 S214 W215 G216	Y47 W50 N95 A193 C194 V218 S219 W220 G221

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2zf0, PDBe:2zf0, PDBj:2zf0
PDBsum	2zf0
PubMed
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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