Structure of PDB 2yze Chain H

Receptor sequence
>2yzeH (length=287) Species: 1665 (Arthrobacter globiformis) [Search protein sequence]
TKVVLGQNQYGKAEVRLVKVTRNTARHEIQDLNVTSQLRGDFEAAHTAGD
NAHVVATDTQKNTVYAFARDGFATTEEFLLRLGKHFTEGFDWVTGGRWAA
QQFFWDRINDHDHAFSRNKSEVRTAVLEISGSEQAIVAGIEGLTVLKSTG
SEFHGFPRDKYTTLQETTDRILATDVSARWRYNTVEVDFDAVYASVRGLL
LKAFAETHSLALQQTMYEMGRAVIETHPEIDEIKMSLPNKHHFLVDLQPF
GQDNPNEVFYAADRPYGLIEATIQREGSRADHPIWSN
3D structure
PDB2yze Trapping of the uric acid substrate in the crystal structure of urate oxidase from Arthrobacter globiformis
ChainH
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K22 T67 R180 Q223 H251
Catalytic site (residue number reindexed from 1) K12 T57 R170 Q213 H241
Enzyme Commision number 1.7.3.3: factor independent urate hydroxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NOB H A66 T67 A56 T57
BS02 NOB H F163 R180 L222 Q223 N249 F153 R170 L212 Q213 N239
Gene Ontology
Molecular Function
GO:0004846 urate oxidase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0019628 urate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2yze, PDBe:2yze, PDBj:2yze
PDBsum2yze
PubMed
UniProtD0VWQ1|URIC_ARTGO Uricase (Gene Name=uox)

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