Structure of PDB 2v74 Chain H

Receptor sequence
>2v74H (length=330) Species: 10090 (Mus musculus) [Search protein sequence]
VQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSG
ILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVS
LPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAP
FTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIR
ILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFI
GSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQ
SYDISIVAQVDQTGSKSSNLLDLKNPFFRY
3D structure
PDB2v74 Insights Into Histone Code Syntax from Structural and Biochemical Studies of Carm1 Methyltransferase
ChainH
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH H F151 Y154 M163 R169 G193 C194 I198 L199 E215 A216 K242 M269 F4 Y7 M16 R22 G46 C47 I51 L52 E68 A69 K95 M122
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2v74, PDBe:2v74, PDBj:2v74
PDBsum2v74
PubMed17882261
UniProtQ9WVG6|CARM1_MOUSE Histone-arginine methyltransferase CARM1 (Gene Name=Carm1)

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