Structure of PDB 2pw8 Chain H

Receptor sequence
>2pw8H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
3D structure
PDB2pw8 Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.
ChainH
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H E23 G25 M26 P28 W29 D116 H119 C122 Y134 K135 R137 N159 M201 K202 P204 N205 R206 W207 E8 G10 M11 P13 W14 D113 H116 C119 Y134 K135 R137 N157 M204 K205 P207 N210 R211 W212
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2pw8, PDBe:2pw8, PDBj:2pw8
PDBsum2pw8
PubMed17685615
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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