Structure of PDB 2hpq Chain H

Receptor sequence
>2hpqH (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
3D structure
PDB2hpq Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin.
ChainH
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0G7 H H57 Y60A W60D L99 I174 D189 A190 S195 W215 G216 H43 Y47 W50 L96 I173 D193 A194 S199 W221 G222 BindingDB: IC50=1.5nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:2hpq, PDBe:2hpq, PDBj:2hpq
PDBsum2hpq
PubMed8387813
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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