Structure of PDB 2hgt Chain H

Receptor sequence
>2hgtH (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FGE
3D structure
PDB2hgt Structure of the hirugen and hirulog 1 complexes of alpha-thrombin.
ChainH
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H H57 Y60A L99 D189 A190 E192 G193 S195 W215 G216 H43 Y47 L96 D193 A194 E196 G197 S199 W221 G222
BS02 peptide H F34 Q38 R73 T74 R75 Y76 F19 Q24 R68 T69 R70 Y71
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2hgt, PDBe:2hgt, PDBj:2hgt
PDBsum2hgt
PubMed1942057
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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