Structure of PDB 2flb Chain H

Receptor sequence
>2flbH (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLR
APFP
3D structure
PDB2flb Discovery of novel hydroxy pyrazole based factor IXa inhibitor.
ChainH
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6NH H C42 H57 D189 S190 C191 K192 S195 V213 W215 G216 C26 H41 D186 S187 C188 K189 S192 V210 W212 G213 PDBbind-CN: -logKd/Ki=5.74,Ki=1.8uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2flb, PDBe:2flb, PDBj:2flb
PDBsum2flb
PubMed16487703
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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