Structure of PDB 2fes Chain H

Receptor sequence
>2fesH (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB2fes Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety.
ChainH
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 K36 Q38 L40 R73 T74 R75 Y76 K81 I82 F19 K21 Q24 L26 R68 T69 R70 Y71 K77 I78
BS02 3SP H H57 Y60A D189 A190 S195 W215 G216 E217 G219 H43 Y47 D192 A193 S198 W220 G221 E222 G223 MOAD: ic50=0.98nM
PDBbind-CN: -logKd/Ki=9.01,IC50=0.98nM
BindingDB: IC50=1nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2fes, PDBe:2fes, PDBj:2fes
PDBsum2fes
PubMed16517159
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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