Structure of PDB 2anm Chain H

Receptor sequence
>2anmH (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB2anm Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety
ChainH
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CDO H H57 Y60A D189 A190 S195 W215 G216 E217 G219 H43 Y47 D192 A193 S198 W220 G221 E222 G223 MOAD: ic50=1.8nM
PDBbind-CN: -logKd/Ki=8.74,IC50=1.8nM
BindingDB: IC50=1nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2anm, PDBe:2anm, PDBj:2anm
PDBsum2anm
PubMed16460939
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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