Structure of PDB 2ank Chain H

Receptor sequence
>2ankH (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB2ank Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety
ChainH
Resolution2.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H K36 Q38 L40 N62 L65 R73 T74 Y76 K81 I82 M84 K21 Q24 L26 N57 L60 R68 T69 Y71 K77 I78 M80
BS02 N12 H L99 D189 A190 S195 S214 W215 G216 E217 G219 L96 D192 A193 S198 S219 W220 G221 E222 G223 MOAD: ic50=47.3nM
PDBbind-CN: -logKd/Ki=7.33,IC50=47.3nM
BindingDB: IC50=47.3nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:2ank, PDBe:2ank, PDBj:2ank
PDBsum2ank
PubMed16460939
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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