Structure of PDB 1wv7 Chain H

Receptor sequence
>1wv7H (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLR
APFP
3D structure
PDB1wv7 Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor
ChainH
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA H E70 D72 E75 E80 E58 D60 E63 E68
BS02 5PI H H57 D60 G97 T98 D170G S170H P170I D189 S190 C191 K192 S195 V213 S214 W215 G216 Q217 G219 H41 D44 G85 T86 D167 S168 P169 D186 S187 C188 K189 S192 V210 S211 W212 G213 Q214 G215 PDBbind-CN: -logKd/Ki=7.26,IC50=55nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1wv7, PDBe:1wv7, PDBj:1wv7
PDBsum1wv7
PubMed15629154
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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