Structure of PDB 1wqv Chain H

Receptor sequence
>1wqvH (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLR
APFP
3D structure
PDB1wqv Crystal structure of human factor VIIa/tissue factor in complex with peptide mimetic inhibitor
ChainH
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA H E70 D72 E75 E80 E58 D60 E63 E68
BS02 PSM H H57 T98 T99 D189 S190 C191 K192 S195 V213 S214 W215 G216 G219 H41 T86 T87 D186 S187 C188 K189 S192 V210 S211 W212 G213 G215 MOAD: ic50=130nM
PDBbind-CN: -logKd/Ki=6.89,IC50=130nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:1wqv, PDBe:1wqv, PDBj:1wqv
PDBsum1wqv
PubMed15504346
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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