Structure of PDB 1w8b Chain H

Receptor sequence
>1w8bH (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGTALELMVLNVPRLMTQD
CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLT
GIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
3D structure
PDB1w8b Selective and Orally Bioavailable Phenylglycine Tissue Factor/Factor Viia Inhibitors
ChainH
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA H E70 D72 E75 H76 E80 E58 D60 E63 H64 E68
BS02 413 H H57 G97 T99 P170I D189 S190 K192 S195 V213 S214 W215 G216 G219 H41 G85 T87 P162 D179 S180 K182 S185 V203 S204 W205 G206 G208 BindingDB: Ki=4nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1w8b, PDBe:1w8b, PDBj:1w8b
PDBsum1w8b
PubMed16213138
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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