Structure of PDB 1w7x Chain H

Receptor sequence
>1w7xH (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTW
YLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
3D structure
PDB1w7x Selective and Orally Bioavailable Phenylglycine Tissue Factor/Factor Viia Inhibitors.
ChainH
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA H E70 D72 E75 E80 E58 D60 E63 E68
BS02 413 H H57 K60A T99 S170H P170I D189 S190 K192 S195 S214 W215 G216 Q217 G219 C220 H41 K45 T87 S164 P165 D182 S183 K185 S188 S207 W208 G209 Q210 G211 C212 MOAD: Ki=0.004uM
PDBbind-CN: -logKd/Ki=8.40,Ki=0.004uM
BindingDB: Ki=4nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1w7x, PDBe:1w7x, PDBj:1w7x
PDBsum1w7x
PubMed16213138
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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