Structure of PDB 1w4r Chain H

Receptor sequence
>1w4rH (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
RGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTREALPACL
LRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQR
KPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFK
3D structure
PDB1w4r Structure of a Type II Thymidine Kinase with Bound Dttp
ChainH
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TTP H M28 G31 K32 S33 D58 R60 D97 E98 Q100 F101 L124 T127 F128 F133 T163 V172 E173 V174 I175 G176 Y181 M11 G14 K15 S16 D41 R43 D67 E68 Q70 F71 L94 T97 F98 F103 T133 V142 E143 V144 I145 G146 Y151
BS02 ZN H C153 C156 C185 C188 C123 C126 C155 C158
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:1w4r, PDBe:1w4r, PDBj:1w4r
PDBsum1w4r
PubMed15733844
UniProtP04183|KITH_HUMAN Thymidine kinase, cytosolic (Gene Name=TK1)

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