Structure of PDB 1w2k Chain H

Receptor sequence
>1w2kH (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGT
WYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPF
P
3D structure
PDB1w2k Design of Selective Phenylglycine Amide Tissue Factor/Factor Viia Inhibitors
ChainH
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 380 H H57 T99 D189 S190 K192 S195 W215 G216 G219 H41 T87 D183 S184 K186 S189 W209 G210 G212 PDBbind-CN: -logKd/Ki=6.46,Ki=0.35uM
BindingDB: Ki=350nM
BS02 CA H E70 D72 L73 E75 E80 E58 D60 L61 E63 E68
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1w2k, PDBe:1w2k, PDBj:1w2k
PDBsum1w2k
PubMed15664864
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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