Structure of PDB 1vzq Chain H

Receptor sequence

>1vzqH (length=250) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTAYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF

3D structure

• PDB: 1vzq Stable Expression and Purification of a Secreted Human Recombinant Prethrombin-2 and its Activation to Thrombin
• Chain: H
• Resolution: 1.54 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	F34 R73 T74 Y76	F19 R68 T69 Y71
BS02	peptide	H	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 N210 R211 W212
BS03	SHY	H	H57 Y60A E97A N98 L99 D189 A190 E192 S214 W215 G216	H43 Y47 E94 N95 L96 D192 A193 E195 S219 W220 G221	MOAD: Ki=36nM PDBbind-CN: -logKd/Ki=7.44,Ki=36nM
BS04	CA	H	K169 T172	K167 T170

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:1vzq, PDBe:1vzq, PDBj:1vzq
• PDBsum: 1vzq
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)