Structure of PDB 1uvs Chain H

Receptor sequence
>1uvsH (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRRYERNIEKISMLEKIYIHPRYNWRNLDRDIAL
MKLKPVAFSDYIHPVCLPDRTAASLLQAGYKGRVTGWGNLKETPSVLQVV
NLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKS
PFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
3D structure
PDB1uvs Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design.
ChainH
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H E23 I24 G25 M26 W29 H119 P120 C122 Y134 K135 R137 N159 M201 K202 R206 W207 E8 I9 G10 M11 W14 H113 P114 C116 Y130 K131 R133 N151 M198 K199 R205 W206
BS02 I11 H Y60A W60D L99 I174 D189 A190 W215 G216 G219 Y47 W50 L94 I166 D186 A187 W214 G215 G217 PDBbind-CN: -logKd/Ki=5.40,Ki=4uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1uvs, PDBe:1uvs, PDBj:1uvs
PDBsum1uvs
PubMed8939759
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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