Structure of PDB 1tmu Chain H

Receptor sequence

>1tmuH (length=257) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF

3D structure

• PDB: 1tmu Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms.
• Chain: H
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E23 M26 W29 S48 D116 H119 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207	E8 M11 W14 S34 D113 H116 C119 Y134 K135 R137 N164 M211 K212 N217 R218 W219
BS02	peptide	H	F34 K36 R67 R73 T74 R75 Y76 R77A K81 I82 M84	F19 K21 R62 R68 T69 R70 Y71 R73 K77 I78 M80
BS03	0G6	H	H57 Y60A W60D L99 D189 A190 S195 S214 W215 G216	H43 Y47 W50 L96 D199 A200 S205 S226 W227 G228

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:1tmu, PDBe:1tmu, PDBj:1tmu
• PDBsum: 1tmu
• PubMed: 8251938
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)