Structure of PDB 1tmt Chain H

Receptor sequence

>1tmtH (length=257) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF

3D structure

• PDB: 1tmt Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms.
• Chain: H
• Resolution: 2.2 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	I16 D21 E23 M26 W29 D116 H119 P120 V121 C122 Y134 K135 R137 N159 M201 K202 P204 N205 R206 W207	I1 D6 E8 M11 W14 D113 H116 P117 V118 C119 Y134 K135 R137 N164 M211 K212 P214 N217 R218 W219
BS02	peptide	H	H57 Y60A N98 L99 D189 A190 S195 W215 G216 F245	H43 Y47 N95 L96 D199 A200 S205 W227 G228 F257
BS03	peptide	H	F34 K36 Q38 L65 R73 T74 Y76 R77A I82	F19 K21 Q24 L60 R68 T69 Y71 R73 I78

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:1tmt, PDBe:1tmt, PDBj:1tmt
• PDBsum: 1tmt
• PubMed: 8251938
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)