Structure of PDB 1qur Chain H

Receptor sequence

>1qurH (length=257) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF

3D structure

• PDB: 1qur Design and evaluation of novel bivalent thrombin inhibitors based on amidinophenylalanines.
• Chain: H
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N164 M211 K212 R218 W219
BS02	peptide	H	F34 P37 Q38 E39 L40 H57 Y60A W60D R73 T74 R75 I82 M84 N98 K110 I174 D189 A190 E192 W215 G216 G219	F19 P23 Q24 E25 L26 H43 Y47 W50 R68 T69 R70 I78 M80 N95 K107 I179 D199 A200 E202 W227 G228 G230

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:1qur, PDBe:1qur, PDBj:1qur
• PDBsum: 1qur
• PubMed: 10504391
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)