Structure of PDB 1p8j Chain H

Receptor sequence
>1p8jH (length=466) Species: 10090 (Mus musculus) [Search protein sequence]
YQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKN
HPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNG
VCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDD
GKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYT
NSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQK
CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAD
DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPK
DIGKRLEVRKAVTACLGEPNHITRLEHVQARLTLSYNRRGDLAIHLISPM
GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIENTSEANN
YGTLTKFTLVLYGTAP
3D structure
PDB1p8j The Crystal Structure of the Proprotein Processing Proteinase Furin Explains its Stringent Specificity
ChainH
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D153 H194
Catalytic site (residue number reindexed from 1) D44 H85
Enzyme Commision number 3.4.21.75: furin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H Y495 Y560 Y386 Y451
BS02 peptide H D154 H194 E236 S253 W254 G255 P256 D258 D264 G294 N295 D306 Y308 S368 D45 H85 E127 S144 W145 G146 P147 D149 D155 G185 N186 D197 Y199 S259
BS03 CA H D115 D162 V205 N208 V210 G212 D6 D53 V96 N99 V101 G103
BS04 CA H D258 D301 E331 D149 D192 E222
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1p8j, PDBe:1p8j, PDBj:1p8j
PDBsum1p8j
PubMed12794637
UniProtP23188|FURIN_MOUSE Furin (Gene Name=Furin)

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