Structure of PDB 1o5g Chain H

Receptor sequence
>1o5gH (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB1o5g Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
ChainH
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 K36 Q38 L65 R67 R73 T74 R75 Y76 I82 M84 F19 K21 Q24 L60 R62 R68 T69 R70 Y71 I78 M80
BS02 CR9 H H57 C58 K60F D189 A190 C191 E192 S195 V213 H43 C44 K52 D192 A193 C194 E195 S198 V218 MOAD: Ki=11uM
PDBbind-CN: -logKd/Ki=4.96,Ki=11uM
BindingDB: Ki=11000nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1o5g, PDBe:1o5g, PDBj:1o5g
PDBsum1o5g
PubMed15522303
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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