Structure of PDB 1o5e Chain H

Receptor sequence
>1o5eH (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVL
SRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFNSNDIALVHLSSPLPL
TEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISN
DVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRW
RLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
3D structure
PDB1o5e Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
ChainH
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.106: hepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 132 H H57 D189 A190 C191 Q192 S195 V213 S214 W215 G219 C220 H41 D178 A179 C180 Q181 S184 V206 S207 W208 G211 C212 MOAD: Ki=1.8uM
PDBbind-CN: -logKd/Ki=5.74,Ki=1.8uM
BindingDB: Ki=1800nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1o5e, PDBe:1o5e, PDBj:1o5e
PDBsum1o5e
PubMed15522303
UniProtP05981|HEPS_HUMAN Serine protease hepsin (Gene Name=HPN)

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