Structure of PDB 1o0d Chain H

Receptor sequence
>1o0dH (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB1o0d D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety
ChainH
Resolution2.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H K36 Q38 L40 L65 R73 T74 R75 Y76 K81 I82 K21 Q24 L26 L60 R68 T69 R70 Y71 K77 I78
BS02 163 H H57 Y60A W60D D189 A190 C191 S195 S214 W215 G216 G219 H43 Y47 W50 D192 A193 C194 S198 S219 W220 G221 G223 MOAD: ic50=6.2nM
PDBbind-CN: -logKd/Ki=8.21,IC50=6.2nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1o0d, PDBe:1o0d, PDBj:1o0d
PDBsum1o0d
PubMed12781189
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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