Structure of PDB 1nrp Chain H

Receptor sequence
>1nrpH (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
VGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDAC
EGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQ
KVIDQFG
3D structure
PDB1nrp Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
ChainH
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H E23 I24 M26 W29 D116 H119 C122 Y134 K135 R137 N159 K202 N205 R206 W207 E8 I9 M11 W14 D113 H116 C119 Y134 K135 R137 N163 K211 N216 R217 W218
BS02 peptide H H57 W60D L99 S195 S214 G216 G219 H43 W50 L96 S204 S225 G227 G229
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1nrp, PDBe:1nrp, PDBj:1nrp
PDBsum1nrp
PubMed8136362
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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