Structure of PDB 1nro Chain H

Receptor sequence
>1nroH (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTV
GKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACE
GDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK
VIDQFGE
3D structure
PDB1nro Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
ChainH
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H E23 I24 M26 W29 D116 H119 C122 Y134 K135 R137 K202 N205 R206 W207 E8 I9 M11 W14 D113 H116 C119 Y134 K135 R137 K210 N215 R216 W217
BS02 peptide H H57 W60D L99 E146 S195 G219 H43 W50 L96 E146 S203 G228
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1nro, PDBe:1nro, PDBj:1nro
PDBsum1nro
PubMed8136362
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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