Structure of PDB 1nrn Chain H

Receptor sequence
>1nrnH (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEKGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
3D structure
PDB1nrn Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
ChainH
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H E23 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 K202 N205 W207 E8 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N157 K205 N210 W212
BS02 peptide H H57 Y60A W60D R173 I174 E192 W215 G216 E217 G219 H43 Y47 W50 R171 I172 E195 W220 G221 E222 G223
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1nrn, PDBe:1nrn, PDBj:1nrn
PDBsum1nrn
PubMed8136362
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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