Structure of PDB 1mkx Chain H

Receptor sequence
>1mkxH (length=255) Species: 9913 (Bos taurus) [Search protein sequence]
IVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDI
ALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTT
SVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDA
CEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVID
3D structure
PDB1mkx The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
ChainH
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H E23 G25 L26 P28 W29 D116 H119 P120 V121 C122 F134 K135 R137 N159 K202 N205 R206 W207 E8 G10 L11 P13 W14 D113 H116 P117 V118 C119 F134 K135 R137 N164 K212 N217 R218 W219
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1mkx, PDBe:1mkx, PDBj:1mkx
PDBsum1mkx
PubMed9232645
UniProtP00735|THRB_BOVIN Prothrombin (Gene Name=F2)

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