Structure of PDB 1ihs Chain H

Receptor sequence

>1ihsH (length=258) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFG

3D structure

• PDB: 1ihs Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
• Chain: H
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	I16 E23 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 R206 W207	I1 E8 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N164 M211 K212 R218 W219
BS02	peptide	H	Q38 L40 L41 H57 Y60A K60F L65 R67 R73 T74 R75 Y76 N98 A149A V149C D189 E192 S195 W215 G216 G246	Q24 L26 L27 H43 Y47 K52 L60 R62 R68 T69 R70 Y71 N95 A150 V152 D199 E202 S205 W227 G228 G258

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:1ihs, PDBe:1ihs, PDBj:1ihs
• PDBsum: 1ihs
• PubMed: 8272424
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)