Structure of PDB 1hxf Chain H

Receptor sequence
>1hxfH (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
3D structure
PDB1hxf The molecular environment of the Na+ binding site of thrombin.
ChainH
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H E23 I24 G25 M26 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 R206 W207 E8 I9 G10 M11 W14 D113 H116 P117 C119 Y134 K135 R137 N156 M203 K204 R210 W211
BS02 peptide H F34 K36 R73 T74 Y76 I82 F19 K21 R68 T69 Y71 I78
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1hxf, PDBe:1hxf, PDBj:1hxf
PDBsum1hxf
PubMed9108691
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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