Structure of PDB 1hxe Chain H

Receptor sequence
>1hxeH (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
3D structure
PDB1hxe The molecular environment of the Na+ binding site of thrombin.
ChainH
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H E23 G25 M26 D116 H119 C122 Y134 K135 R137 N159 M201 K202 R206 W207 E8 G10 M11 D113 H116 C119 Y134 K135 R137 N156 M203 K204 R210 W211
BS02 peptide H F34 R73 T74 Y76 I82 M84 F19 R68 T69 Y71 I78 M80
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1hxe, PDBe:1hxe, PDBj:1hxe
PDBsum1hxe
PubMed9108691
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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