Structure of PDB 1hut Chain H

Receptor sequence
>1hutH (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FGE
3D structure
PDB1hut The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.
ChainH
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna H I24 H71 R75 Y76 E77 R77A I79 I9 H66 R70 Y71 E72 R73 I75
BS02 0G7 H H57 Y60A W60D N98 L99 I174 D189 A190 C191 S195 S214 W215 G216 H43 Y47 W50 N95 L96 I173 D193 A194 C195 S199 S220 W221 G222 BindingDB: IC50=1.5nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1hut, PDBe:1hut, PDBj:1hut
PDBsum1hut
PubMed8102368
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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