Structure of PDB 1hdt Chain H

Receptor sequence
>1hdtH (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
3D structure
PDB1hdt Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.
ChainH
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 R73 T74 Y76 K81 I82 M84 F19 R68 T69 Y71 K77 I78 M80
BS02 0E7 H H57 Y60A W60D D189 A190 C191 E192 S195 S214 W215 G216 E217 G219 C220 H43 Y47 W50 D199 A200 C201 E202 S205 S226 W227 G228 E229 G230 C231 PDBbind-CN: -logKd/Ki=7.76,Ki=17.2nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1hdt, PDBe:1hdt, PDBj:1hdt
PDBsum1hdt
PubMed7853394
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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