Structure of PDB 1h8d Chain H

Receptor sequence

>1h8dH (length=251) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G

3D structure

• PDB: 1h8d Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate
• Chain: H
• Resolution: 1.4 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	S20 M26 S27 F34 L41 C42 C58 L65 V66 S72 R73 T74 R75 Y76 K81 I82 S83 L85 I90 V138 T139 V157 R165 C168 K169	S5 M11 S12 F19 L27 C28 C44 L60 V61 S67 R68 T69 R70 Y71 K77 I78 S79 L81 I86 V138 T139 V155 R163 C166 K167
BS02	peptide	H	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 N210 R211 W212
BS03	PHW	H	H57 Y60A W60D E146 I174 A190 C191 E192 S195 W215 G216 E217 G219 C220	H43 Y47 W50 E146 I172 A193 C194 E195 S198 W220 G221 E222 G223 C224

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:1h8d, PDBe:1h8d, PDBj:1h8d
• PDBsum: 1h8d
• PubMed: 11493008
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)