Structure of PDB 1gj5 Chain H

Receptor sequence
>1gj5H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB1gj5 Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.
ChainH
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H Q38 L65 R73 T74 R75 Y76 I82 Q24 L60 R68 T69 R70 Y71 I78
BS02 130 H C42 H57 C58 W60D D189 A190 E192 S195 V213 C28 H43 C44 W50 D192 A193 E195 S198 V218 PDBbind-CN: -logKd/Ki=4.96,Ki=11uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:1gj5, PDBe:1gj5, PDBj:1gj5
PDBsum1gj5
PubMed11731301
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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