Structure of PDB 1ghy Chain H

Receptor sequence
>1ghyH (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB1ghy A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
ChainH
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 K36 Q38 L40 L65 R73 T74 R75 Y76 I82 M84 F19 K21 Q24 L26 L60 R68 T69 R70 Y71 I78 M80
BS02 ZN H H57 S195 H43 S198
BS03 121 H H57 W60D D189 A190 C191 E192 S195 S214 G216 G219 H43 W50 D192 A193 C194 E195 S198 S219 G221 G223 MOAD: Ki=0.008uM
PDBbind-CN: -logKd/Ki=8.10,Ki=0.008uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ghy, PDBe:1ghy, PDBj:1ghy
PDBsum1ghy
PubMed11292354
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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