Structure of PDB 1fph Chain H

Receptor sequence
>1fphH (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
3D structure
PDB1fph The interaction of thrombin with fibrinogen. A structural basis for its specificity.
ChainH
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 K36 L65 R73 T74 R75 Y76 R77A K149E F19 K21 L60 R68 T69 R70 Y71 R73 K154
BS02 peptide H H57 Y60A W60D R97 E97A L99 R173 I174 D189 A190 S195 S214 W215 G216 H43 Y47 W50 R93 E94 L96 R178 I179 D199 A200 S205 S226 W227 G228
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1fph, PDBe:1fph, PDBj:1fph
PDBsum1fph
PubMed1587268
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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