Structure of PDB 1c5n Chain H

Receptor sequence
>1c5nH (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
3D structure
PDB1c5n Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
ChainH
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 L65 R73 T74 R75 Y76 I82 F19 L60 R68 T69 R70 Y71 I78
BS02 CA H K169 T172 K167 T170
BS03 ESI H D189 S195 G216 G219 D192 S198 G221 G223 MOAD: Ki=20uM
PDBbind-CN: -logKd/Ki=4.70,Ki=20uM
BindingDB: Ki=20000nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1c5n, PDBe:1c5n, PDBj:1c5n
PDBsum1c5n
PubMed10779411
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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