Structure of PDB 1c1v Chain H

Receptor sequence
>1c1vH (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
3D structure
PDB1c1v Design of potent selective zinc-mediated serine protease inhibitors.
ChainH
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 K36 Q38 L40 L65 R73 T74 R75 Y76 I82 F19 K21 Q24 L26 L60 R68 T69 R70 Y71 I78
BS02 ZN H H57 S201 H43 S198
BS03 BAB H K60F D195 A196 E198 W221 G222 G225 K52 D192 A193 E195 W220 G221 G223 MOAD: Ki=0.023uM
PDBbind-CN: -logKd/Ki=7.64,Ki=0.023uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1c1v, PDBe:1c1v, PDBj:1c1v
PDBsum1c1v
PubMed9468142
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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