Structure of PDB 1bmm Chain H

Receptor sequence

>1bmmH (length=258) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFG

3D structure

• PDB: 1bmm Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.
• Chain: H
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	S20 E23 I24 G25 M26 P28 W29 F114 D116 H119 P120 C122 Y134 K135 R137 N159 K202 P204 N205 R206 W207	S5 E8 I9 G10 M11 P13 W14 F111 D113 H116 P117 C119 Y134 K135 R137 N164 K212 P214 N217 R218 W219
BS02	peptide	H	F34 L65 R73 T74 Y76 I82	F19 L60 R68 T69 Y71 I78
BS03	BM2	H	H57 Y60A W60D L99 E192 S195 W215 G216 E217 G219	H43 Y47 W50 L96 E202 S205 W227 G228 E229 G230	PDBbind-CN: -logKd/Ki=7.10,Ki=79nM BindingDB: IC50=390nM

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:1bmm, PDBe:1bmm, PDBj:1bmm
• PDBsum: 1bmm
• PubMed: 8745399
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)