Structure of PDB 1abi Chain H

Receptor sequence
>1abiH (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
3D structure
PDB1abi Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.
ChainH
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 Q38 E39 L40 L41 H57 Y60A K60F R73 T74 R75 Y76 K81 I82 M84 N98 L99 Q151 I174 D189 C191 E192 G193 S195 W215 G216 G219 F19 Q24 E25 L26 L27 H43 Y47 K52 R68 T69 R70 Y71 K77 I78 M80 N95 L96 Q149 I172 D192 C194 E195 G196 S198 W220 G221 G223
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1abi, PDBe:1abi, PDBj:1abi
PDBsum1abi
PubMed1445905
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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