Structure of PDB 1a2c Chain H

Receptor sequence
>1a2cH (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
3D structure
PDB1a2c The Structure of a Complex of Recombinant Hirudin and Human Alpha-Thrombin
ChainH
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 Q38 L65 R73 T74 R75 Y76 K81 I82 F19 Q24 L60 R68 T69 R70 Y71 K77 I78
BS02 peptide H Y60A W60D D189 C191 S195 W215 G216 E217 G219 R221A Y47 W50 D192 C194 S198 W220 G221 E222 G223 R226
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1a2c, PDBe:1a2c, PDBj:1a2c
PDBsum1a2c
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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