Structure of PDB 4v8p Chain GV

Receptor sequence

>4v8pGV (length=234) Species: 5911 (Tetrahymena thermophila)

PENVQKKLARDEKLRKAKAEQRKASSAQMKQRKAEWISKAQKYAAEYEAA
EKKIVDEKRKARKTGAFYVPAEAKVAFAIRIRGVNQLHPDVKRVLRLFRL
RQLHNGAFFRVNKASLNMIKRVLPFITFGYPTRNTISKLIYKRGFAKVNG
QRIPLTDNTIVEKSLGKFGITCVEDLIHEITTVGPHFKEANNFLWPFKLD
TPRGGFRNKRHAYHQGGDWGNREVYINDLVKAML

3D structure

• PDB: 4v8p Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6.
• Chain: GV
• Resolution: 3.52 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	GV	R215 H216 H219 Q220 W224	R210 H211 H214 Q215 W219
BS02	rna	GV	N8 K11 K12 R15 R27 S31 M34 K38 W41 K63 R64 R67 K68 R87 G88 N90 Q91 P94 D95 R98 V99 R101 L102 R106 Q107 L108 H109 R115 N117 K118 A119 N122 M123 N139 K143 K147 Q156 R157 D162 K193 N197 K203 L204 D205 T206 P207 R208 G210 F211 K214 R215	N3 K6 K7 R10 R22 S26 M29 K33 W36 K58 R59 R62 K63 R82 G83 N85 Q86 P89 D90 R93 V94 R96 L97 R101 Q102 L103 H104 R110 N112 K113 A114 N117 M118 N134 K138 K142 Q151 R152 D157 K188 N192 K198 L199 D200 T201 P202 R203 G205 F206 K209 R210

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v8p, PDBe:4v8p, PDBj:4v8p
• PDBsum: 4v8p
• PubMed: 22052974
• UniProt: P0DJ13|RL7_TETTH Large ribosomal subunit protein uL30 (Gene Name=RPL7)