Structure of PDB 9bpa Chain G

Receptor sequence
>9bpaG (length=739) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPT
SAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIK
VDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE
LHMLGDSHRGYLLELLLTKICYITRKSASSNAVQIVGMSATLPNLELVAS
WLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVDHVVSLC
YETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEQKELLEVMDQL
RRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATS
TLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESIL
ICKNSEKSKGIALLQGSLKPVRSCLVTGSMIRAILEIIVGGVASTSQDMH
TYAACTFLAASMGAIEACVMWLLENEFIQSTKVYHPTHLGSATLSSSLSP
ADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEK
LPTSMKRVAELVGVEEGFLARCVKGKQHRQMAIHKRFFTSLVLLDLISEV
PLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQ
KRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVI
LKNAVPMRTIWVTGRKGLTEREAAALIVEEARMILQQDL
3D structure
PDB9bpa Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM.
ChainG
Resolution3.21 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WCN G F181 E192 R193 G196 L197 R200 E204 S621 S622 V757 M761 Q782 F114 E125 R126 G129 L130 R133 E137 S496 S497 V625 M629 Q650
External links
PDB RCSB:9bpa, PDBe:9bpa, PDBj:9bpa
PDBsum9bpa
PubMed39143110
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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