Structure of PDB 8vfz Chain G

Receptor sequence

>8vfzG (length=121) Species: 9606 (Homo sapiens)

GKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEY
LTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGV
LPNIQAVLLPKKTESHHKAKG

3D structure

• PDB: 8vfz Cryo-EM structure of FoxA1 in complex with ALBN1 nucleosome (class 1)
• Chain: G
• Resolution: 4.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	G	G8 K9 R11 A12 A14 K15 R17 R20 R29 R32 R42 R77 E121 S122 H123 H124	G1 K2 R4 A5 A7 K8 R10 R13 R22 R25 R35 R70 E114 S115 H116 H117
BS02	dna	G	R11 K13 R29 R42 V43 G44 A45 T76 R77 K118 H124 K125 A126 K127 G128	R4 K6 R22 R35 V36 G37 A38 T69 R70 K111 H117 K118 A119 K120 G121

External links

• PDB: RCSB:8vfz, PDBe:8vfz, PDBj:8vfz
• PDBsum: 8vfz
• PubMed: 39121853
• UniProt: P04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)