Structure of PDB 8ttw Chain G

Receptor sequence

>8ttwG (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]

QIHLVQSGTEVKKPGSSVTVSCKAYGVNTFGLYAVNWVRQAPGQSLEYIG
QIWRWKSSASHHFRGRVLISAVDLTGSSPPISSLEIKNLTSDDTAVYFCT
TTSTYDRWSGLHHDGVMAFSSWGQGTLISVSAASTKGPSVFPLAPSSTAA
LGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS
SLGTQTYICNVNHKPSNTKVDKRVEPK

3D structure

PDB

8ttw Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.

Chain

Resolution

2.96 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	BMA	G	S70 A71	S70 A71
BS02	MAN	G	S70 I77D S79	S70 I81 S83
BS03	MAN	G	T19 S70 E81	T19 S70 E85
BS04	MAN	G	S57 G65 V67	S57 G65 V67

External links

PDB	RCSB:8ttw, PDBe:8ttw, PDBj:8ttw
PDBsum	8ttw
PubMed	37872202

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